High resolution microscope for live cell imaging

| Environmental Testing

Researchers in biology and healthcare now have access to a super resolution microscope with high image acquisition speeds for live cell imaging.

The new Olympus SD-OSR microscope system features both confocal and super-resolution modes. The technology combines 120-nanometer (nm) resolution, a cell depth penetration of more than 50 microns, and an image speed of three frames per second (3fps) for advanced live cell imaging. The combination of resolution, depth, excellent contrast levels, and ultra-fast super-resolution imaging speeds gives researchers the flexibility to view subtle and dynamic processes taking place deep within cells.

Microscopes with super-resolution have made it possible to view cells with increasingly high resolution. However, many super-resolution systems suffer from poor contrast and slow image acquisition. The SD-OSR microscope system uses a high-speed Yokogawa CSU-W1 scan unit paired with an Olympus 100X silicone-immersion objective with its high (1.35) numerical aperture, a high-resolution sCMOS camera, powerful signal processing software and the IX83 inverted microscope. This combination of hardware and software delivers excellent resolution, contrast and cell penetration depths for deep cell and tissue imaging with live-cell super-resolution 3D sectioning.

Olympus designed the SD-OSR microscope system to be easy to use. It features both laser confocal and super-resolution modes so that researchers have the flexibility to undertake different types of imaging using a single platform. The software provides the user with control over various hardware settings and has advanced signal processing capabilities so that even individuals who have minimal training can attain good quality images. The system can process and display super-resolution images during the image acquisition process making it easier for researchers to locate the area of interest.

The Olympus SD-OSR combination laser confocal super-resolution microscope features excellent resolution (120 nm), cell depth (50 microns or more), speed (3 fps) and a user-friendly design to provide researchers with flexibility for live cell research and observing intracellular structures or tissues. The SD-OSR maintains excellent resolution while preserving a high level of contrast. Olympus is committed to making advanced technologies accessible to the life science research community with easy to use and flexible systems.

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